As a geneticist seeing patients in the clinic, I think the challenges are really with creating the internal structures of having the right tools. When you see that there is actually a higher diagnostic yield from doing that internal re-analysis, that really pushes the boundaries of what should be standard clinical practice. Virtual Geneticist is a really high throughput tool. And really is multimodal because it’s not just allowing you to explore unreported variants, but really is allowing you to adjust the phenotype see what the variant ranking relationships are, as well as contextualize the reported variants of uncertain significance (VUS).

As the director of large clinical labs and population level initiatives, I have seen the growth in both the possibilities and also the complexity of whole genome testing. Nothing compares to Virtual Geneticist and its cutting-edge tools for providing accurate genome interpretation at scale. The platform is unique in providing a literature database that is easy to access and highlights all of the evidence I need to evaluate each VUS variant. The fact that this information is then automatically integrated into updated ACMG and ClinGen classifications is an important achievement that will have lasting benefits for all of us working in the field.

As a Medical Geneticist, I am frequently perplexed by negative genetic test reports that I receive back from a commercial lab when I am convinced that the patient has a genetic disorder. By using Virtual Geneticist, I am able to analyze the data files and verify on my own what are the most likely variants that explain the patient's disease. The platform's straightforward interface makes it easy for me.

As a genetic scientist I can say that Virtual Geneticist has brought the way we analyze our whole genome sequencing results to a whole new level. It provides unparalleled access to the variant data often buried deep in the publications and easily missed. We now have much more confidence in the analysis of each sample.