Virtual Geneticist is a modular genomic interpretation platform that helps clinical laboratories accelerate variant review, improve diagnostic yield, and scale testing warkflows, from variant-level analysis to end-to-end case interpretation and reporting.
Supporting Every Expert Behind Every Diagnosis
Clinical Lab Directors
For clinical lab directors, Virtual Geneticist® eliminates the single biggest constraint on lab throughput :variant interpretation. Virtual Geneticist automates ACMG v4 classification, standardizes variant review across every reviewer, and replaces legacy tools with audit-ready, reproducible workflows — so staff limitations are less of a concern. Directors get the consistency, defensibility, and scalability to increase volume and test complexity with fixed resources.
Geneticists
For medical geneticists, Virtual Geneticist® amplifies genetic expertise by streamlining literature review, in silico evidence evaluation, and criterion-level ACMG v4 reasoning. The platform surfaces relevant evidence and supports transparent classification workflows, helping geneticists review cases faster without losing interpretive control. Geneticists can focus on the complex cases where their judgment matters most: rare variants, ultra-rare presentations, challenging phenotypes, and VUS interpretations with conflicting evidence.
Variants Scientists and Counselors
Variant scientists and genetic counselors get comprehensive evidence all in one place including transparent, criterion-level ACMG reasoning across the full spectrum of variant types - SNV’s/Indels, CNV’s, trinucleotide repeats, UPDs, mitochondrial variants, intronic variants, and more. With Virtual Geneticist, each classification is supported by concise literature overviews of each paper and clear reasoning.
Bioinformatics
Virtual Geneticist provides distinct options for integration from end-to-end deployment to optional API access for seamless access from existing clinical workflows and pipelines. The platform supports FASTQ, BAM, and VCF inputs across all major sequencing platforms and provides multi-sample processing and RNA and long-read sequencing data compatibility without custom engineering. The result is a scalable, easy-to-maintain interpretation layer that stays up-to-date even as volumes grow or test menus expand.
As genomic testing expands, clinical laboratories are expected to interpret more variants, support more complex cases, reduce turnaround times, and maintain consistent quality — often with limited specialist capacity and legacy platforms that were not built for today’s interpretation demands.
Trusted by Laboratories Solving Complex Cases
Virtual Geneticist is designed specifically to address the following operational and clinical challenges:
Match Virtual Geneticists to Your Workflow
Select modular solutions to match your needs from variant annotation to full rare disease diagnosis with four purpose-built modules from single variant annotation all the way to clinical reports, newborn screening, and beyond.
- VG - Variant
- Virtual Geneticist
- Virtual Geneticist plus
- AI Genetics Research Agent
Improve Diagnostic Yield
Virtual Geneticist helps laboratories uncover clinically relevant findings that may otherwise be missed through advanced variant prioritization and comprehensive evidence integration.
- Correctly ranks causal variants in #1 position more often than the competition
- Increases diagnostic yield by +10%
- Resolves VUS variants
- 99% accuracy in ranking variants in Top 10
Reduce Manual Interpretation Burden
Virtual Geneticist aggregates structured evidence, interpreted literature, database references, and ACMG support into a unified workflow — reducing the need for repetitive manual review.
Tasks Virtual Geneticist automates:
- Literature Review
- ACMC Evidence Scoring
- Phenotype Entry
- Variant Prioritization
- Clinical Reporting
Accelerate Turnaround Times
Virtual Geneticist's automated workflows and scalable interpretation capabilities help laboratories process larger case volumes more efficiently without compromising review quality.
Turnaround Time Improvements:
- Faster case triage
- Shorter evidence review cycles
- More efficient report preparation
- Scalable support as test volumes grow
Analyze Difficult Variant Classes
Virtual Geneticist provides specific tools and filters to detect and interpret a wide range of the most challenging classes of genetic variants.
Interpretation for difficult genomic regions and variants include:
- SNVs/Indels
- CNVs and structural variants
- trinucleotide repeats
- variants with low penetrance
- variants with high homology loci
- mitochondrial variants
- intronic variants
- complex star alleles
Core Platform Capabilities
From data import to clinical report in four simple steps
01
Advanced
Variant
Prioritization
Virtual Geneticist uses sophisticated Al-powered prioritization that helps laboratories rapidly identify clinically relevant variants.
02
Structured
Literature
Interpretation
Virtual Geneticist includes a fully-integrated interpreted literature database with instant access to more than 15 million structured variantpublications.
03
Automated ACMG
Classification Support
Virtual Geneticist streamlines ACMG interpretation workflows while preserving reviewer oversight and laboratory control.
04
End-to-End Analysis and Reporting
Virtual Geneticist supports various NGS interpretation and reporting workflows within a unified, cloud-based platform.
Introducing the Virtual Geneticist Modules
VG Variant
A scalable variant annotation and interpretation engine designed to help contextualize and resolve difficult and rare variants.
- Comprehensive literature-backed evidence
- ACMG Classification System with multi-factorial scoring, full user control, and optional phenotype entry
- API-ready architecture for seamless workflow integration
Virtual Geneticist
A genomic interpretation platform designed for rare disease diagnosis in high-throughput clinical labs, hospitals, and undiagnosed disease programs.
- Advanced variant prioritization and phenotype-driven analysis
- Automated natural language processing of clinical notes and patient phenotypes
- Parallel sample processing for scalable case analysis
Virtual Geneticist Plus
End-to-end solution for customized NGS analysis and reporting for use in clinical labs, newborn screening programs, and a variety of WGS applications.
- AI-Powered Filters for Fully-Customized Analysis
- Comprehensive Interpretation of Complex Variants Types
- Integrated Pipeline for Secondary Analysis
AI Genetics Research Agent
A genomics-focused research and translational medicine assistant for biopharma, clinical genomics, and specialty interpretation teams.
- Customizable interactive assistant for genomics-specific questions
- Literature-cited answers with clear supporting rationale
Improve Diagnostic Yield.
Reduce Interpretation Burden.
Scale with Confidence.
Contact Us Today
